← Back to browse
skill

DNase-seq pipeline for accessibility and footprints

From ammawla/encode-toolkit ★ 34

Summary

Executes a comprehensive DNase-seq workflow, processing paired-end FASTQ reads to identify DNase hypersensitive sites (DHSs) and perform transcription factor footprinting. The pipeline leverages Nextflow to manage alignment, peak calling via Hotspot2, and subsequent analysis for chromatin accessibility profiling.