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skill
DNase-seq pipeline for accessibility and footprints
From ammawla/encode-toolkit ★ 34
Summary
Executes a comprehensive DNase-seq workflow, processing paired-end FASTQ reads to identify DNase hypersensitive sites (DHSs) and perform transcription factor footprinting. The pipeline leverages Nextflow to manage alignment, peak calling via Hotspot2, and subsequent analysis for chromatin accessibility profiling.